منابع مشابه
Role of Matrix Metalloproteinases in Atherosclerosis: Pathophysiological and Therapeutic Implications
Atherosclerosis continues to cause considerable morbidity and mortality in the Western countries. In response to cardiovascular risk factors, a cascade of compensatory structural events occurs within the vessel wall. It has become increasingly evident that significant alterations in the structure and composition of the extracellular matrix (ECM) play a key role in the atherogenic process. Far f...
متن کاملAliskiren Inhibits Neointimal Matrix Metalloproteinases in Experimental Atherosclerosis.
BACKGROUND The renin-angiotensin system (RAS) plays an important role in atherosclerosis. Acting via the angiotensin II receptor, type 1, oxidative stress increases and contributes to endothelial dysfunction and vascular inflammation. Renin exerts effects through a renin receptor causing an increase in the efficiency of angiotensinogen cleavage and facilitates angiotensin II (Ang II) generation...
متن کاملMatrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis.
M atrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, which are highly activated by inflammatory signaling, including that of angiotensin II (Ang II; Figure). Activated MMPs are able to degrade col-lagen, elastin, and other extracellular molecules, 2 probably resulting in aging, hypertension, and atherosclerotic effects within the arterial wall (for reviews). The modi...
متن کاملP 88: Matrix Metalloproteinases in Neuroinflammation
Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
متن کاملEvaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach.
OBJECTIVE Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease in the Western world. This is because our means of identifying truly vulnerable patients is limited. Prediction of atherosclerotic plaque rupture may be addressed by MRI of activated matrix metalloproteinases (MMPs), a family of enzymes that have been implicated in the vulnera...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2017
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2017.09.007